RESOURCES.

A selection of helpful resources below...

The following research is provided in support of the noted benefits of fulvic. If the summaries here ignite your curiosity feel free to click on the links provided to access the full script or, where the paper is not freely available, the option to purchase a copy.

Complexation of Furosemide with fulvic acid extracted from Shilajit: a novel approach

Furosemide (FSM) was complexed with fulvic acid and the effect on the aqueous solubility, dissolution rate and permeability was investigated. Results found a 23-fold increase in solubility of FSM when complexed with FA. In addition, 86.9% of the drug was released in 60 minutes, versus 3% in the same period without FA. Finally, the permeability was improved by 10 times concluding that FA was able to significantly enhance the bioavailability of FSM. 

-       Agarwal, SP, Anwer, MH and Aqil, M, 2008, Complexation of Furosemide with fulvic acid extracted from Shilajit: a novel approach, Drug Development and Industrial Pharmacy, 34, 506-511

Disclaimer: People taking prescription medicines should check with their doctor before taking NZ Fulvic 

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Effect of fulvic acids on the electrolytes physiology in vertebrates

The behavior of the mineral ions, iron and iodine, when they are escorted by fulvic acids was investigated in mice. In the presence of FA, iron was entirely fixed in red blood cells and iodine fixed in the thyroid gland, both by factors larger than two, compared to when FA was not present. This suggests that the ingestion, fixation and elimination of mineral ions in vertebrates is a dynamic process greatly accelerated when they are escorted by fulvic acids.  

-       Morales, OY, Navarrete, JM, Gracia, I, Macias, L, Rivera, M and Sanchez, F, 2011, Effect of fulvic acids on the electrolytes physiology in vertebrates, Nuclear Instruments and Methods in Physics Research, 652, 838-840

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Inclusion of solid state aspirin with fulvic acid: dissolution, permeability, stability and preliminary pharmacological studies

Aspirin, a low water soluble compound with poor bioavailability, was complexed with fulvic acid to investigate dissolution and permeation properties. The release profile (dissolution rate) of aspirin increased from 31.32% in 30 minutes without FA, to 99.7% in 25 minutes when complexed with FA. The permeation of the FA-Aspirin complex across an everted rat gut sac was 8 times greater than compared to aspirin alone. As such, FA was concluded to be beneficial in enhancing the bioavailability of aspirin. 

-       Anwer, MK, Jamil, S, Ahmad, M, Ansari, MN and Khan, TH, 2013, Inclusion complex of solid state aspirin with fulvic acid: dissolution, permeability, stability and preliminary pharmacological studies, Journal of Biological Sciences, 13, 5, 302-312

Disclaimer: People taking prescription medicines should check with their doctor before taking NZ Fulvic 

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Effect of fulvic acid on oral delivery of Carbamazepine

Carbamazepine (CBZ) has poor bioavailability due to its low water solubility. As such, the complexation of CBZ with fulvic acid was explored to determine the effect of FA on bioavailability parameters. FA increased the solubility of CBZ by 2268.75%, and also demonstrated a better release profile of approximately 81% in 60 minutes. Further, the permeability of CBZ across everted rat gut sac increased 3 fold. Complexation of FA with CBZ was concluded as a promising tool for enhancing the bioavailability of CBZ.  

-       Mirza, MA, Agarwal, SP and Iqbal, Z, 2011, Effect of Fulvic Acid on Oral Delivery of Carbamazepine, Science of Advanced Materials, 3, 1-10

Disclaimer: People taking prescription medicines should check with their doctor before taking NZ Fulvic 

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